Week 1 NFL Injury Update: Henderson, Nacua Among Key Concerns

As the NFL kicks off its 2026 season, teams are already grappling with injuries that could shape early matchups. The most talked‑about absences include Treveyon Henderson, a rookie defensive tackle, and Puka Nacua, a veteran offensive lineman. Both players are listed as questionable or out, prompting roster adjustments and strategic shifts for their respective teams.

Treveyon Henderson: A Rookie’s Early Setback

Henderson, drafted in the second round by the New England Patriots, suffered a hamstring strain during preseason training. The injury was first reported in the team’s injury report on Monday, and medical staff confirmed he will miss the first two weeks of the season. While the Patriots have a depth chart that can absorb his absence, the loss of a young interior lineman may affect their defensive line’s pass‑rush potency.

Puka Nacua: Veteran Lineup Adjustments

Formerly a key guard for the San Francisco 49ers, Nacua was listed as questionable for Week 1 after a groin injury. The 49ers’ coaching staff indicated that he could be activated if his recovery progresses, but the current status is “out” for the opening game. The team has promoted a backup guard to fill the gap, but the change could influence the offensive line’s protection scheme against the league’s top pass rushers.

Other Notable Absences

In addition to Henderson and Nacua, the injury list includes a handful of other players across the league. Teams are scrambling to find replacements, and some are turning to practice squad members or free‑agent signings. The ripple effect of these injuries may be felt in early-season matchups, especially for teams that rely heavily on their line play.

What This Means for Week 1 Matchups

With key linemen out, both the Patriots and the 49ers may face challenges in controlling the trenches. Opponents could exploit the weakened lines, potentially leading to more sacks and rushing yards for the opposing teams. Coaches will need to adjust their game plans, possibly shifting to a more pass‑heavy or run‑heavy approach depending on the injury impact.

For a deeper dive into the injury reports and how they affect team strategies, check out the full Fox Sports article.

Watch and listen free on JASTORM – Follow radio and video broadcasts free in the JASTORM app with your free account.